FIGURE 1.

Imiquimod (IMQ)‐induced psoriasis and upregulation of GRP and GRPR in the spinal dorsal horn (SDH). A, Schedule of the IMQ application and photograph and psoriasis area and severity index (PASI) score of the IMQ‐treated mice on days 0, 4, 7, and 10. n = 5. ***P < .001 vs. control. B, Scratching bouts were observed on days 4, 7, and 10 before IMQ application up to 40 min, and the total number of scratching bouts is shown. n = 6‐10. **P < .01, *P < .05 vs. control. C, The mRNA expression levels of GRP and GRPR on days 0, 4, 7, and 10 in the cervical SDH were evaluated by RT‐qPCR. n = 5‐6. *P < .05 vs. control