Figure 3.

Forced swim test and assessment of locomotor activity. (A) Forced swim test. Although CUS did not induce stress responses compared with nonstress controls, BHB administration shortened the immobility time in both the nonstress and the CUS group. P < .05 for comparisons between nonstress + PBS vs nonstress + BHB and CUS + PBS vs CUS + BHB. (B) Open field test. The OFT was conducted to determine whether locomotor activity correlated with the changes in immobility time observed in the FST. There was no significant difference between the groups. Error bars represent the standard error of the mean (SEM). FST, forced swim test; CUS: chronic unpredictable stress; BHB: beta‐hydroxybutyrate; PBS: phosphate‐buffered saline; OFT, open field test