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. 2020 Dec 8;10:21397. doi: 10.1038/s41598-020-78167-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gfi1 enhances Atoh1-induced hair cell regeneration in the adult cochlea. Images show cochleae of adult mice 4 weeks after DT-induced HC (HC) ablation and adenovirus injection into scala media. The tdTomato (tdTom) reporter is robustly expressed in OC epithelial cells in both cochlear turns (a). Mice that received Ad.Atoh1 had fewer Myosin VIIa positive cells in both apical and basal turn than mice that received Ad.Gfi1.Atoh1. Higher magnification images (b) show that Myosin VIIa-positive cells are large, variable in shape but usually round, and all co-express tdTom. Linear regression analysis (c) shows that the proportion of tdTom-positive cells that were also Myosin VIIa-positive were similar in the apex and base for both treatments and differed between treatments (see text for details). Scale bar = 100 μm.