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. 2020 Dec 8;10:21397. doi: 10.1038/s41598-020-78167-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Long term survival of hair cell-like cells. 8 weeks after transgene delivery, there were still numerous Myosin VIIa-positive/tdTomato-positive HCLCs in both treatment groups (a). Scatter plots showing counts of Myosin VIIa-positive and tdTomato-positive cells (b) demonstrate patterns similar to those seen at 4 weeks; namely, similar proportions tdTomato-positive cells that are Myosin VIIa-positive in the apex and base of each group, and a higher proportion of Myosin VIIa-positive/tdTomato-positive cells in the Ad.Gfi1.Atoh1 group than in the Ad.Atoh1 group. The total number of new Myosin VIIa-positive cells was significantly higher in the Ad.Gfi1.Atoh1 group than in the Atoh1-only group (c); although difference were not significant due to small sample size at the 8-week time point. Scale bar = 100 μm.