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. 2020 Dec 8;10:21486. doi: 10.1038/s41598-020-78473-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Doxorubicin administration perturbs the tight junctional network in T84 cells. Representative images of immunofluorescent staining of ZO-1 and Occludin after DXR application to T84 cells, n = 3 for each time point. Aggregates of ZO-1 and Occludin (arrowheads) suggest an internalization of tight junctions. Uneven pulling of the cytoskeleton on the tight junctional network is observed as sinusoidal irregularities (arrows). Occludin pseudo-colored red for clarity. Scale bar 20 μm.