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. 2020 Dec 8;10:21486. doi: 10.1038/s41598-020-78473-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Doxorubicin in vivo increases permeability to small molecules in mouse jejunum. (A) TER measurements of conventionally raised (CONV) animals (n = 3/group). (B) TER measurements of germ free (GF) animals (n = 3/group). (C,D) Macromolecular flux measurements of jejunal tissue isolated from CONV mice (n = 4/group). FITC-Dextran molecules of 4 kDa (C) and 10 kDa (D) were applied to the mucosal side at 24 h post-DXR (40 µg/mL), and the fluorescence of the serosal chamber was measured after flux. Student’s t-test; *p < 0.05; **p < 0.01; ns no significance.