Table 1.
Probability of impact on function (PIF) of variants based on cell survival (HAT) and drug sensitivity (DS) assay results individually and combined (HAT + DS).
| VARIANT | PIF[HAT] | PIF[DS] | PIF[HAT + DS]a | VARIANT | PIF[HAT] | PIF[DS] | PIF[HAT + DS]a |
|---|---|---|---|---|---|---|---|
| K16R | 0.2624 | 0.0584 | 0.0258 (F) | Q2561P | 1 | NA | 1 (NF) |
| P168T | 0.0026 | 0.2426 | 0 (F) | F2562L | 1 | NA | 1 (NF) |
| K169R | 0.0148 | 0.4618 | 0.0038 (F) | G2585R | 1 | NA | 1 (NF) |
| V220Ifs | 1 | 1 | 1 (NF) | L2587F | 0.0020 | 0.0454 | 0 (F) |
| F266L | 0.0864 | 0.2936 | 0.0438 (F) | G2596R | 1 | NA | 1 (NF) |
| N277K | 0.0018 | 0.0854 | 0 (F) | G2596E | 1 | NA | 1 (NF) |
| L452V | 0.0024 | 0.0594 | 0 (F) | D2611G | 1 | NA | 1 (NF) |
| T598A | 0.0008 | 0.0342 | 0 (F) | N2622S | 0.0192 | 0.3164 | 0.0020 (F) |
| T598I | 0.0036 | 0.1472 | 0 (F) | H2623R | 1 | NA | 1 (NF) |
| G637 = | 0.1164 | 0.0312 | 0.0002 (F) | K2630Q | 1 | NA | 1 (NF) |
| Q742X | 1 | NA | 1 (NF) | L2647P | 1 | NA | 1 (NF) |
| S869L | 0.0078 | 0.0330 | 0 (F) | R2659G | 1 | NA | 1 (NF) |
| N986S | 0.0074 | 0.0460 | 0 (F) | R2659K | 1 | NA | 1 (NF) |
| N986I | 0.0024 | 0.1616 | 0 (F) | R2659T | 1 | NA | 1 (NF) |
| M1300I + 1301Tdel | 0.0076 | 0.0504 | 0 (F) | S2670L | 1 | NA | 1 (NF) |
| T1302del | 0.0076 | 0.6654 | 0.0132 (F) | T2681R | 0.0028 | 0.1666 | 0 (F) |
| E1308X | 1 | NA | 1 (NF) | L2686P | 1 | NA | 1 (NF) |
| S1479T | 0.0010 | 0.0654 | 0 (F) | L2688P | 1 | NA | 1 (NF) |
| F1524V | 0 | 0.0436 | 0 (F) | S2691F | 1 | NA | 1 (NF) |
| G1529R | 0.0176 | 0.1146 | 0 (F) | T2708Nfs | 1 | 0.9950 | 1 (NF) |
| T1624A | 0.0110 | 0.9554 | 0.0518 (I) | L2721H | 1 | NA | 1 (NF) |
| V1643A | 0.0032 | 0.0710 | 0 (F) | D2723A | 1 | NA | 1 (NF) |
| D1781N | 0.1906 | 0.0478 | 0.0038 (F) | D2723V | 1 | NA | 1 (NF) |
| D1781G | 0.0090 | 0.1744 | 0 (F) | Y2726C | 1 | NA | 1 (NF) |
| N1880K | 0.0086 | 0.0892 | 0.0052 (F) | V2728I | 0.0148 | 0.8716 | 0.1034 (I) |
| S1882X | 1 | NA | 1 (NF) | V2739I | 0.0302 | 0.0506 | 0 (F) |
| K1883N | 0.0074 | 0.0458 | 0 (F) | L2740X | 1 | NA | 1 (NF) |
| I1884T | 0.0386 | 0.7680 | 0.1540 (I) | R2784W | 0.9952 | 0.9724 | 0.9998 (NF) |
| S1926Rfs | 1 | NA | 1 (NF) | A2786P | 1 | NA | 1 (NF) |
| H1996Y | 0.0024 | 0.0428 | 0 (F) | W2788S | 0.0516 | 0.9976 | 0.9444 (I) |
| L2106P | 0.0084 | 0.1610 | 0 (F) | G2793R | 1 | NA | 1 (NF) |
| S2152Y | 0.0636 | 0.2396 | 0.0272 (F) | Q2829X | 1 | NA | 1 (NF) |
| G2281V | 0.0150 | 0.0422 | 0.0008 (F) | Q2829L | 1 | NA | 1 (NF) |
| D2312V | 0.0010 | 0.2830 | 0 (F) | Q2829R | 1 | NA | 1 (NF) |
| D2312E | 0.0022 | 0.0374 | 0.0002 (F) | P3063S | 0.1998 | 0.1978 | 0.1278 (I) |
| R2336L | 0.1960 | 0.7516 | 0.3642 (I) | D3064N | 0.0004 | 0.0566 | 0 (F) |
| R2336P | 0.9684 | 0.9770 | 0.9990 (NF) | D3064Y | 0.0100 | 0.0688 | 0 (F) |
| K2411T | 0.0058 | 0.1364 | 0.0002 (F) | F3065L | 0.0236 | 0.0448 | 0.0006 (F) |
| S2483G | 0.0440 | 0.1100 | 0 (F) | Q3066E | 0.0152 | 0.0336 | 0.0004 (F) |
| S2483N | 0.0038 | 0.1072 | 0 (F) | C3069X | 1 | 0.9924 | 1 (NF) |
| R2488Rfs | 1 | NA | 1 (NF) | D3073 G | 0.8888 | 0.9996 | 0.9966 (NF) |
| R2488K | 0.0096 | 0.2200 | 0.0048 (F) | Y3225Ifs | 1 | NA | 1 (NF) |
| R2488S | 0.0022 | 0.0590 | 0 (F) | C3233Wfs | 0.9996 | 0.9744 | 1 (NF) |
| D2489G | 1 | 0.1672 | 1 (NF) | Y3308X | 1 | 0.9392 | 1 (NF) |
aFunctional classification indicated in parenthesis. F functional, NF nonfunctional, I indeterminate, NA not available.