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. 2020 Dec 8;10:21475. doi: 10.1038/s41598-020-78359-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RNA expression profiles of HIO donors resemble human colonic mucosa. Heatmap representation of the RNA expression profile of 72 genes defining colonic identity in 3 HIO donors grown in microfluidic or standard HIO culture conditions for 8 days, compared with human normal colon from study GSE9254³¹ and human normal small intestine sections (duodenum, jejunum, ileum) from study GSE14938³⁰. Genes with higher levels of expression are represented in red and genes with lower levels of expression in blue.