Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 8;10:21475. doi: 10.1038/s41598-020-78359-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Induction of inflammatory conditions upregulates pathways involved in cytokine and immune signaling in IEC. (A) Heatmap representation of the top 30 differentially expressed genes between normal (untriggered) and inflammatory conditions (LPS 100 ng/mL, IFN-γ 20 ng/mL) in 3 different HIO donors. IEC were grown under microfluidic conditions for 8 days and triggered for 24 h. Heatmap shows gene expression levels (adjusted p value). Genes with higher expression values are shown in red and genes with lower expressions values in blue. (B) Based on significantly changed gene sets between normal and inflammatory conditions, functional Gene ontology (GO) pathways were isolated. Circle size represents gene counts and color gradation represents adjusted p values. (C,D) The top 30 differentially expressed genes were queried against toxic pathologies (C) and pathways (D) in Metacore. Graphs show false discovery rate (FDR) values.