Figure 5.

Telmisartan downregulates IL6 expression in M1 by activation of PPARG and inhibition of NFKB-p65

(a), Involved protein nodes between IL6 and CD274 (PD-L1) illustrated in STRING PPI map. Nodes size and color represent their connection degree with other proteins in the map. Lines between nodes represent the interactions between them. Red lines mark out the pathway that connects PPARG, NFKB, and IL6. (b), Western blot detection of PPARG, t-NFKB p65, pi-NFKB p65, and ELISA detection of IL6 in M0 and M1 treated with telmisartan, PPARG selective inhibitor T0070907 or NFKB transcriptional activity inhibitor JSH-23, respectively. The symbol * represents a significant difference (P < .05).