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. 2020 Sep 23;123(12):1720–1729. doi: 10.1038/s41416-020-01074-2

Fig. 3. Genetic alteration profile in patient-derived xenograft models.

Fig. 3

a Somatic mutations in known cancer-related genes based on the Cancer Gene Census for all seven PDX models (first panel); mutation rates for all seven PDX models (second panel); relative proportions of functional consequences (third panel); and signatures (fourth panel). b Genome-wide somatic copy number alteration profiles of seven PDX models using whole-exome sequencing data. Asterisks indicate the cases with NS/S (nonsynonymous/synonymous) ratios less than 2.0.