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. 2020 Dec 8;10:21491. doi: 10.1038/s41598-020-77990-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Efficacy of prioritized candidate peptides against VEEV TC-83. (A) Cytotoxicity of prioritized peptides in HMC3 cells; cells were pre-treated with peptides and toxicity was quantified at 24 h post-treatment; reported as % vs. water control. (B) TC-83 replication in peptide-treated HMC3 cells; reported as plaque forming units (PFU) per mL. Cells were treated with 10 µg/mL of each peptide. (C) TC-83 replication in U87MG cells treated with peptides A2 or A3. (D) and (E) Fold change in intracellular and extracellular genomic TC-83 RNA in peptide-treated HMC3 cells respectively; reported as fold change compared to water control. (F) Synergistic effects of A2 and A3 on TC-83 replication in HMC3 cells; reported as PFU/mL. n = 3; **p > 0.01; ***p > 0.001.