Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 8;10:21491. doi: 10.1038/s41598-020-77990-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

A2 and A3 treatment inhibits upregulation of the inflammatory response genes following VEEV infection. (A) Schematic of peptide treatment and TC-83 infection in U87MG cells (hpt = hours post treatment; n = 1). (B) Heat maps depicting the fold change in gene expression of PCR array performed following A2 pre-treatment of infected cells compared to water control. Red is maximum increase for IL7 gene expression. (C) Heat map of gene expression in A3 treated samples. Red depicts maximum expression for BMP2 gene; Orange depicts CCL16, CCL22, and IL1RN genes; Beige depicts IL7 and VEGFA genes. Scale: Blue, decrease in gene expression; Red, increase in gene expression. (D)–(F) Decrease in the gene expression of pro-inflammatory cytokines IL1α, IL1β, and TNF respectively in peptide treated cells. (G) and (H) Increase in the expression of anti-inflammatory genes IL1RN and IL7 respectively in peptide treated cells. (I) Increase in gene expression of genes involved in chemotaxis of leukocytes, CCL22 and CCL16, as a result of peptide treatment.