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. 2020 Dec 8;11:6296. doi: 10.1038/s41467-020-20141-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Volcano plot with up- or downregulated genes in Acly-deficient macrophages (BMDMs) highlighted in red or blue, respectively. b Ridgeline plot of significantly enriched Reactome pathways. Log₂FC distributions of member genes are plotted on the x axis. Color of the distributions represents enriched pathway P value. c Expression of genes involved in import/transport of cholesterol and fatty acids, and genes that promote cholesterol efflux. d Schematic view of cholesterol metabolism and the effect of Acly deficiency (red indicating upregulation; blue downregulation). e Desmosterol levels in control and Acly-deficient macrophages. f Genes previously found to be induced by desmosterol, plotted in a heatmap for control and Acly^M-KO macrophages. g Cholesterol levels in control and Acly-deficient macrophages. h Acss2 expression in control and Acly-deficient macrophages. Values represent mean from n = 2 technical replicates from three pooled mice e, g, or mean ± SEM n = 3 technical replicates from three pooled mice (h). Source data are provided as a Source Data file e, g or deposited in GSE126690 (a–d, f, h).