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. 2020 Dec 8;6:38. doi: 10.1038/s41531-020-00139-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Dopaminergic terminals within the striatum (tyrosine hydroxylase; TH; red) were significantly reduced compared to the contralateral side in animals expressing AAV2-αSyn/GFP, but not in animals expressing AAV2-TOM20/αSyn; TH (red), αSyn (cyan), GFP (green); (F(5, 95 = 3.0), p = 0.0146, ANOVA; a, b). Representative images from the ipsilateral and contralateral hemispheres of each treatment group show significant dopaminergic neuron loss (TH, red) following AAV2-αSyn/GFP treatment, which was reduced by co-expression with TOM20 (AAV2-TOM20/αSyn); (F(5, 20 = 12.07), p < 0.0001, ANOVA); scale bars 100 μm (c, d). Error bars depict standard error of the mean (s.e.m.).