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. 2020 Dec 8;6:38. doi: 10.1038/s41531-020-00139-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — NADH:Ubiquinone Oxidoreductase Core Subunit S3 (NDUFS3, white) is a component of complex I of the electron transport chain. NDUFS3 expression is significantly reduced in dopaminergic neurons of animals expressing AAV2-αSyn/GFP, and rescued by AAV2-TOM20 co-expression; TOM20 (red), GFP (green), TH (blue); (F(2, 10 = 11.82), p = 0.0023, ANOVA; (a, b). Succinate dehydrogenase complex flavoprotein subunit A (SDHA, yellow) encodes the catalytic subunit of succinate-ubiquinone oxidoreductase of the electron transport chain, was reduced within mitochondria of dopaminergic neurons following αSyn overexpression, and rescued by AAV2-TOM20 co-expression; TOM20 (white), TH (magenta); (F(2, 23 = 14.57), p = 0.0001, ANOVA; c, d). Cytochrome c oxidase or complex IV (COX IV, red) the final enzyme in the mitochondrial transport chain, displayed a significant reduction within mitochondria in dopaminergic neurons expressing AAV2-αSyn/GFP, but not neurons expressing AAV2-TOM20/αSyn; TOM20 (red), TH (green); (F(2, 23 = 8.46), p = 0.0018, ANOVA; e, f). Error bars depict standard error of the mean (s.e.m.).