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. 2020 Dec 8;10:21407. doi: 10.1038/s41598-020-78522-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Alterations in lipid profile in platelets from Apoe^−/− and Ldlr^−/− mice. Highly purified platelets from wild-type, Apoe^−/− and Ldlr^−/− mice were used for quantitative lipidomic analysis. (A) Cholesterol and (B) cholesteryl esters (ChoE); (C) ceramides (Cer); (D) sphingosine (So); E) sphingosine-1-phosphate (S1P); F) glycosylceramide or galactosylceramide (HexCer); (G) lactosylceramide (Hex2Cer); (H) Sphingomyelin (SM); (I) sphinganine (Sa). Means ± SEM (n = 4–6 animals/group), *P < 0.05, **P < 0.01, ***P < 0.001 (Mann–Whitney U test). (J) Cluster analysis of quantitative lipidome analysis. Significantly altered lipid classes of Apoe^−/− or Ldlr^−/− platelets compared to wild-type platelets (log2 transformed) are indicated in red (increased) or in green (decreased).