Table 3. Prediction of variants of exon7 in FGFR3 with different software .

HGVS Genomic Change	Driver Statement	Prediction index	Features	MamPhCons	MamPhyloP	Phred Score
Chr4: 1803568C>A	Predicted driver: tier1	Disease-Causing	Spl, pr affected*	0.999	1.9	22.9
Chr4: 1803570C>A	Predicted passenger	Disease-Causing	Spl, pr affected*	0.998	1.9	22.7
Chr4: 1803611G>T	Predicted passenger	Disease-Causing	Spl, pr affected*	1	1.9	23.8
Chr4: 1803704T>C	Polymorphism	Polymorphism	-	0.94	-1.001	2.721
Chr4: 1803735T>C	Predicted passenger	Disease-Causing	pr affected*	1	1.575	23.7

Spl: Splicing site, pr: protein