Table 4. Prediction of variants of exon15 in FGFR3 with different software .

HGVS Genomic Change	Driver Statement	Prediction Index	Features	MamPhCons	MamPhyloP	Phred Score
chr4: 1807824A>T	Predicted driver: tier1	Disease-Causing	Spl, pr affected*	1	1.668	26.9
chr4: 1807840C>T	Not protein affected	Disease-Causing	Spl, pr affected*	0.285	-1.681	14.4
chr4: 1807876C>T	Not protein affected	Disease-Causing	Spl, praffected*	0.77	-1.959	11.03
chr4: 1807879C>A	Predicted passenger	Disease-Causing	Spl, pr affected*	0.996	0.373	23.7
chr4: 1807882C>A	Predicted passenger	Disease-Causing	Spl, pr affected*	1	0.946	38
chr4: 1807894G>A	Polymorphism	Polymorphism	Spl, pr affected*	0.999	0.067	7.653
chr4: 1807915G>T	Not protein affected	Polymorphism	Spl, pr affected*	0	0.431	7.367
chr4: 1807922G>A	Polymorphism	Polymorphism	Spl, pr affected*	0	0.176	1.103
chr4: 1807956C>A	Not protein affected	Polymorphism	Spl, pr affected*	0.001	0.058	0.767
chr4: 1807964G>A	Not protein affected	Polymorphism	Spl, pr affected*	0	0.698	0.074
chr4: 1807965C>A	Not protein affected	Polymorphism	Spl, pr affected*	0	0.053	0.393
chr4: 1807966C>A	Not protein affected	Polymorphism	Spl, pr affected*	0	0.007	0.609
chr4: 1807967T>A	Not protein affected	Polymorphism	Spl, pr affected*	0	0.069	0.854

Spl: Splicing site, pr: protein