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. 2020 Sep 24;123(12):1749–1756. doi: 10.1038/s41416-020-01087-x

Fig. 4. Lysosomal sequestration of sunitinib.

Fig. 4

a 786-O cells were treated with sunitinib with or without lonafarnib, stained with Hoechst and Lysotracker Red, and imaged as described in “Methods”. b 786-O cells were treated as described in a. The number of sunitinib containing vesicles per cell was calculated as described in Materials and Methods. Data are presented as the mean ± S.D. ***P < 0.0001. c The total cellular accumulation of sunitinib was not affected by lonafarnib. 786-O cells were treated as described in a. The samples were run on Becton Dickinson FACScan flow cytometer and analysed using FlowJo software.