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. 2020 Sep 22;123(12):1737–1748. doi: 10.1038/s41416-020-01088-w

Fig. 5.

Fig. 5

a–c After A549 and H460 cells were transfected with PPARɣ siRNA, they were treated with CB11 (30 μΜ), and cell viability and LDH assays were performed along with western blot analyses examining the levels of PPARɣ, p-ATM, p-p53, GADD45α and cleaved caspase-3; *p < 0.05. β-actin was used as a protein loading control. d–f PPARɣ shRNA stable H460 cell lines were established by transfection with PPARɣ shRNA, these cells established PPARɣ shRNA. These cells were treated with CB11 (30 μΜ), GW9662 (20 μM), and CB11 + GW9662, and cell viability and LDH assays were performed along with Western blot analyses examining the levels of PPARɣ, p-ATM, p-p53, GADD45α, and cleaved caspase-3; *p < 0.05. β-actin was used as a protein loading control.