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Effects of miR-139-5p on the expression of AKT, PI3K and caspase-3 mRNA in DDP-treated cells. The relative expression levels of PI3K, AKT and caspase-3 in cells were determined by reverse transcription-quantitative PCR. mRNA expression of (A) PI3K and (B) AKT were not significantly altered, whereas (C) caspase-3 was upregulated significantly in DDP-treated A549 cells after transfection with miR-139-5p mimics. **P<0.01. miR, microRNA; NC, negative control; DDP, cisplatin.
