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. 2020 Dec 3;23(2):113. doi: 10.3892/mmr.2020.11752

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Copyright: © Kanno et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Correlation between the severity of cardiotoxicity after DOX administration and blood mRNA expression of Sod3 (A), Gpx3 (B) or Mt1 (C) before DOX administration. The severity of DOX-induced cardiotoxicity was scored by the changes in tissue injury parameters. The correlation in individual mice was determined by the Spearman correlation function and regression analysis. The correlation coefficient and statistical significance are presented in each figure. DOX, doxorubicin; Sod3, superoxide dismutase-3; Gpx3, glutathione peroxidase-3; Mt1, metallothionein-1.