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. Author manuscript; available in PMC: 2020 Dec 8.
Published in final edited form as: J Med Chem. 2019 Nov 18;62(22):10182–10203. doi: 10.1021/acs.jmedchem.9b01065

Figure 5. Structure activity relationship summary.

Figure 5.

(a) Compound 7 docked into the TOP2A ATP binding site highlighting fluorine H-bond interaction (black dashed line). (b) Similarly, the trifluoromethyl group of 32 forms fluorine H-bonds with Arg98 (black dashed lines). (c) The SAR summary of TOP2A inhibitors, demonstrating water solubility with compound 42.