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. 2020 Dec 8;15(12):e0243386. doi: 10.1371/journal.pone.0243386

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© 2020 Cunningham et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — 100 randomly selected initial tumor compositions used in the Forwards Backwards Sweep optimal control analysis. All initial total tumor volumes satisfy the patient viability constraint $\sum_{i \in T} x_{i} (t_{0}) \leq 9000$ .