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. 2020 Dec 8;15(12):e0243386. doi: 10.1371/journal.pone.0243386

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© 2020 Cunningham et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 12 — The initial tumor compositions of the patients that did not breach the patient viability constraint within the simulation time for each of the six clinically feasible protocols. Their two dimensional projections are available in S9 in S1 File. (A) Maximum tolerable dose. (B) Adaptive therapy. (C) Λ(t₀) = 1 stabilizing at V_a. (D) Λ(t₀) = 0 stabilizing at V_a. (E) Λ(t₀) = 1 stabilizing at V_b. (F) Λ(t₀) = 0 stabilizing at V_b.