Fig 6. HD5 increases the binding of viruses to cells regardless of infection phenotype.

AF488-labeled HAdV-5, HAdV-64, and chimeric viruses were incubated with or without HD5 and then allowed to bind to A549 cells in the cold (as in Fig 4, protocol 1). Data are the fold change in geometric mean fluorescence (GMF) of cells bound by the respective labeled virus incubated with the indicated HD5 concentrations relative to no HD5 for each virus. Each point is an independent experiment, and bars are the mean ± SD of 3–4 independent experiments. Differences between each genotype and HAdV-5 at each HD5 concentration are not significant by ordinary two-way ANOVA with Dunnett’s multiple comparison test.