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. Author manuscript; available in PMC: 2020 Dec 8.
Published in final edited form as: Nat Chem Biol. 2020 Mar 9;16(5):529–537. doi: 10.1038/s41589-020-0496-y

Figure 2. SAR study using synthesized dequalinium analogs.

Figure 2.

(a) Design of five compounds with varying length of the linker (n) of 6, 8, 10, 12, 14 carbons. The 10-carbon-linker compound is dequalinium. (b) Design of eight dequalinium analogs with different head groups. (c) Synthesized compounds were analyzed in the cell-cell fusion assay. (d) Synthesized compounds were analyzed in the ATP-based cytotoxicity assay. DEQ, dequalinium. The experiment was performed in triplicates and repeated independently at least twice with similar results. The error bars represent the standard deviations calculated by the Excel STDEV function.