Figure 1. che-5(e1073) carries mutations in gcy-22 that are responsible for chemotaxis defects of the mutants.

(A) Schematic diagram of gcy-22a gene structure. Boxes represent exons. Protein domains and the nucleotide substitutions found in e1073 are indicated above and below the diagram, respectively. (B) Complementation test between che-5(e1073) and gcy-22(tm2364). Salt concentration chemotaxis was observed in e1073/tm2364 heterozygotes and their parental strains. e1073 failed to complement tm2364. n = 5, Mean±SEM, *p ≤ 0.001, compared to mIs11, Dunnett’s test. (C) ASER-specific expression of gcy-22(+) rescued the chemotaxis defect of the che-5(e1073) mutants. n = 4 or 5, Mean±SEM, *p ≤ 0.01, compared to wild type, Dunnett’s test.