TABLE 2.
n | EFS | OS | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
2-year survival | 95% CI | p-value | 2-year survival | 95% CI | p-value | |||||
All patients | 67 | 56.6 | 44.2 | 72.5 | — | 79.2 | 67.4 | 93.2 | — | |
Type | 1st CR | 44 | 60.7 | 44.9 | 82.0 | 0.21 | 80.2 | 65.1 | 98.8 | 0.40 |
Primary refractory | 23 | 47.1 | 29.4 | 75.3 | 77.2 | 59.6 | 100.0 | |||
Gender | Female | 29 | 44.0 | 27.0 | 71.4 | 0.023 | 76.2 | 59.1 | 98.3 | 0.50 |
Male | 38 | 66.6 | 51.4 | 86.3 | 82.2 | 67.0 | 100.0 | |||
Age at diagnosis | <4 years | 42 | 73.3 | 60.9 | 88.2 | 0.013 | 78.3 | 63.6 | 96.4 | 0.26 |
≥4 years | 25 | 20.6 | 6.7 | 63.9 | 81.0 | 62.8 | 100.0 | |||
MYCN | Amplified | 12 | 50.0 | 28.4 | 88.0 | 0.35 | 50.9 | 24.6 | 100.0 | 0.088 |
Not amplified | 54 | 58.5 | 44.8 | 76.5 | 85.7 | 74.1 | 99.0 | |||
Cycles | 5 or less | 14 | 40.0 | 20.2 | 79.2 | 0.12 | 92.9 | 80.3 | 100.0 | 0.55 |
More than 5 | 53 | 63.1 | 49.9 | 79.7 | 72.1 | 56.2 | 92.4 | |||
Previous ASCT | No | 54 | 54.2 | 40.1 | 73.2 | 0.28 | 84.1 | 72.2 | 97.9 | 0.81 |
Yes | 13 | 64.1 | 40.2 | 100.0 | 66.7 | 42.0 | 100.0 | |||
Previous RDT | No | 27 | 58.6 | 37.3 | 91.9 | 0.55 | 91.2 | 80.2 | 100.0 | 0.65 |
Yes | 40 | 54.8 | 40.5 | 74.2 | 75.6 | 60.9 | 93.9 | |||
MRD | No | 51 | 53.9 | 39.6 | 73.3 | 0.58 | 73.3 | 58.9 | 91.1 | 0.21 |
Yes | 16 | 64.6 | 43.6 | 95.8 | 100.0 | 100.0 | 100.0 |