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. 2020 Nov 2;47(1):302–314. doi: 10.3892/ijmm.2020.4777

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Copyright: © Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Astragaloside IV reduces the protein expression levels of cleaved caspase-3. (A and B) The protein expression levels of cleaved caspase-3 in the rat brain and PC12 cells following different treatments were examined by western blotting. (A) Representative rat brain tissue western blot images from each group. (B) Relative protein expression levels of cleaved caspase-3 in the rat brain. n=3. ^*P<0.05 vs. Sham; ^#P<0.05 vs. MCAO/R. (C) Representative western blot images from each group of PC12 cells. (D) Relative expression levels of cleaved caspase-3 in PC12 cells. n=3. ^*P<0.05 vs. Control; ^#P<0.05 vs. OGD/R and NPS-2143. MCAO/R, middle cerebral artery occlusion/reperfusion; OGD/R, oxygen and glucose deprivation/reoxygenation; CaSR, calcium-sensing receptor; AST-IV, MCAO/R or OGD/R + Astragaloside IV; NPS-2143, MCAO/R or OGD/R + CaSR antagonist.