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. 2020 Nov 25;47(1):161–170. doi: 10.3892/ijmm.2020.4799

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Construction of RS and SIPS models of HMSCs. (A) Diagram illustrating the inducing process of the RS model. HMSCs were continually cultured in normal medium from G0 to G15. (B and C) SA-β-Gal staining showing the G15 HMSCs displaying obvious senescence following culture for 55 days. (D) Diagram illustrating the induction process of the SIPS model by 5% FBS plus 50 µM H₂O₂. (E and F) SA-β-Gal staining showing the premature senescence of HMSCs. HMSCs, heart mesenchymal stem cells; RS, replicative senescence; SIPS, stress-induced premature senescence.