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. 2020 Nov 25;47(1):161–170. doi: 10.3892/ijmm.2020.4799

Figure 2.

Figure 2

Detection of age-related genes expression by RT-PCR. (A and B) RT-PCR showing p16, p27, p53 and p21 mRNA expression in the (A) RS and (B) SIPS models. (C-F) Densitometric analysis showing that the p16, p27 and p53 mRNA expression levels were increased in the RS model. *P<0.05 and **P<0.01 as compared with the G0 group; ##P<0.01 as compared with the G5 group; &P<0.05 as compared with the G10 group. (G-J) Densitometric analysis showing that the p16 and p27 mRNA expression levels were increased in the SIPS model. **P<0.01 as compared with the CT group. M, molecular weight; NS, not significant; HMSCs, heart mesenchymal stem cells; RS, replicative senescence; SIPS, stress-induced premature senescence.