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miR-4428 targets FUT2 in OA. (A) Predicted binding sites of miR-4428 and FUT2 mRNA. (B) FUT2 expression following circCSNK1G1 knock-down in the rat model of OA. (C) Detection of luciferase activity to confirm the association between miR-4428 and FUT2. (D) Expression of FUT2 in cultured chondrocytes. *P<0.05, **P<0.01. (E) Correlation analysis between miR-4428 and FUT2 mRNA expression in patients with OA (n=10, r=−0.7597). OA, osteoarthritis; FUT2, fucosyltransferase 2.
