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. 2020 Oct 27;47(1):232–242. doi: 10.3892/ijmm.2020.4772

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Copyright: © Xiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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miR-4428 inhibits chondrocyte apoptosis by targeting FUT2. (A) Expression of FUT2 in cultured chondrocytes. (B) Expression of FUT2 following FUT2 siRNA knockdown. (C) Proliferation assays of cultured chondrocytes. (D and E) Percentage of apoptotic cells detected by flow cytometry assay. (F-J) Expression of Bax, Bcl-2, Cyt-c, MMP-13, collagen II and aggrecan in cultured chondrocytes was detected by western blot analysis or RT-qPCR ^*P<0.05, ^**P<0.01, ^***P<0.001, ^****P<0.0001). OA, osteoarthritis; Cyt-c, cytochrome c; MMP-13, matrix metalloproteinase 13.