Table 3. Toxicity according to CTCAE4.0.

Type of toxic reaction	Total (n=88)			Pem + S-1 + Bev (n=21)			Other regimens (n=67)			P value
	All grade	3/4 grade		All grade	3/4grade		All grade	3/4 grade		All grade	3/4 grade
Blood system, n (%)
Leukopenia	30 (34.1)	10 (11.4)		11 (52.4)	3 (14.3)		19 (28.4)	7 (10.4)		0.043*	0.929
Neutropenia	30 (34.1)	14 (15.9)		11 (52.4)	6 (28.6)		19 (28.4)	8 (11.9)		0.043*	0.14
Agranulocytosis	0	0		0	0		0	0		–	–
Anemia	19 (21.6)	1 (1.1)		4 (19.0)	0		15 (22.4)	1 (1.5)		0.983	0.761
Thrombocytopenia	16 (18.2)	2 (2.3)		5 (23.8)	0		11 (16.4)	2 (3.0)		0.658	0.578
Bleeding	2 (2.3)	0		1 (4.8)	0		1 (1.5)	0		0.368	–
Digestive system, n (%)
Loss of appetite	5 (5.7)	0		2 (9.5)	0		3 (4.5)	0		0.74	–
Nausea and vomiting	1 (1.1)	0		0	0		1 (1.5)	0		0.761	–
Diarrhea	1 (1.1)	0		0	0		1 (1.5)	0		0.761	–
Elevated alanine aminotransferase	12 (13.6)	0		4 (19.0)	0		8 (11.9)	0		0.643	–
Elevated aspartate aminotransferase	20 (22.7)	0		4 (19.0)	0		16 (23.9)	0		0.871	–
Elevated bilirubin	6 (6.8)	0		2 (9.5)	0		4 (6.0)	0		0.946	–
Urinary system, n (%)
Elevated serum creatinine	1 (1.1)	0		0	0		1 (1.5)	0		0.761	–
Elevated blood urea nitrogen	2 (2.3)	0		0	0		2 (3.0)	0		0.578	–
Proteinuria	10 (11.4)	0		6 (28.6)	0		4 (6.0)	0		0.014*	–
Hematuria	6 (6.8)	0		2 (9.5)	0		4 (6.0)	0		0.946	–
Other regimens, n (%)
Fatigue	2 (2.3)	0		1 (4.8)	0		1 (1.5)	0		0.368	–
Rash	3 (3.4)	0		1 (4.8)	0		2 (3.0)	0		0.423	–
Oral ulcer	1 (1.1)	0		0	0		1 (1.5)	0		0.761	–
Edema	1 (1.1)	0		0	0		1 (1.5)	0		0.761	–

*, P<0.05. Pem, Pemetrexed; Bev, Bevacizumab.