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. 2020 Nov;8(21):1458. doi: 10.21037/atm-20-7024

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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STAT3 inhibitor reduced damage in the BBB through downregulating miR-181b in vivo. (A,B) Assessment of serum D-lactate, TNF-α, IL-6, and IL-8 in the serum and brain homogenates of sham, septic, and Stattic rats by ELISA; (C) Brain vascular permeability as detected by EBD leakage in the sepsis, Stattic, and sham rats (n=3). Extracted dye contents in the formamide extracts were measured at 620 nm; (D) The relative expression of miR-181b in the serum and cerebral cortex of sham, septic, and Stattic rats. **, P<0.01; ***, P<0.001 compared with sham rats; ^#, P<0. 05; ^###, P<0.001 compared with septic rats. IL-6, interleukins 6; IL-8, interleukins 8; TNF-α, tumor necrosis factor alpha; EBD, Evans blue dye; miR-181b, microRNA-181b.