Table 1. Baseline data of patients.
| All stage III patients (n=8,726) | Stage IIID patients (n=505) | ||||||
|---|---|---|---|---|---|---|---|
| Male (n=5,370) | Female (n=3,356) | P value | Male (n=370) | Female (n=135) | P value | ||
| Age, years (%) | 57.0±15.7 | 53.9±18.0 | <0.001 | 59.1±15.5 | 61.2±18.1 | 0.121 | |
| <35 | 487 (9.1) | 523 (15.6) | <0.001 | 30 (8.1) | 11 (8.1) | 0.090 | |
| 35–54 | 1,705 (31.8) | 1,186 (35.3) | 100 (27.0) | 35 (25.9) | |||
| 55–74 | 2,490 (46.4) | 1,164 (34.7) | 176 (47.6) | 48 (35.6) | |||
| ≥75 | 688 (12.8) | 483 (14.4) | 64 (17.3) | 41 (30.4) | |||
| Location (%) | |||||||
| Head and neck | 1,022 (19.0) | 322 (9.6) | <0.001 | 75 (20.3) | 13 (9.6) | <0.001 | |
| Trunk | 2,265 (42.2) | 958 (28.6) | 144 (38.9) | 32 (23.7) | |||
| Upper limb and shoulder | 1,122 (20.9) | 787 (23.5) | 48 (13.0) | 19 (14.1) | |||
| Lower limb and hip | 951 (17.7) | 1,284 (38.3) | 101 (27.3) | 71 (52.6) | |||
| Others | 10 (0.2) | 5 (0.1) | 2 (0.5) | 0 (0) | |||
| Subtype of melanoma (%) | |||||||
| Superficial spreading | 1,373 (25.6) | 884 (26.3) | 0.357 | 56 (15.1) | 16 (11.9) | 0.571 | |
| Nodular | 1,379 (25.7) | 774 (23.1) | 150 (40.5) | 65 (48.1) | |||
| Lentigo maligna melanoma | 47 (0.9) | 27 (0.8) | 1 (0.3) | 0 (0) | |||
| Acral lentiginous | 153 (2.8) | 134 (4.0) | 19 (5.1) | 12 (8.9) | |||
| Others | 281 (5.2) | 135 (4.0) | 23 (6.2) | 5 (3.7) | |||
| Melanoma not specified | 2,137 (39.8) | 1,402 (41.8) | 121 (32.7) | 37 (27.4) | |||
| Clark classification (%) | |||||||
| II | 102 (1.9) | 90 (2.7) | 0.103 | 1 (0.3) | 0 (0) | 0.857 | |
| III | 565 (10.5) | 352 (10.5) | 8 (2.2) | 3 (2.2) | |||
| IV | 3,300 (61.5) | 2,082 (62.0) | 144 (38.9) | 49 (36.3) | |||
| V | 690 (12.8) | 409 (12.2) | 160 (43.2) | 70 (51.9) | |||
| Unknown | 713 (13.3) | 423 (12.6) | 57 (15.4) | 13 (9.6) | |||
| Breslow thickness (mean ± SD) (%) | 316.3±241.2 | 290.5±231.5 | <0.001 | 727.9±205.2 | 699.3±208.6 | 0.234 | |
| <1.0 mm | 664 (12.4) | 483 (14.4) | <0.001 | 0 (0) | 0 (0) | 0.457 | |
| 1.1–2.0 mm | 1,539 (28.7) | 1,120 (33.4) | 0 (0) | 0 (0) | |||
| 2.1–4.0 mm | 1,800 (33.5) | 1,030 (30.7) | 0 (0) | 0 (0) | |||
| >4 mm | 1,359 (25.3) | 715 (21.3) | 369 (99.7) | 134 (99.3) | |||
| Unknown | 8 (0.1) | 8 (0.2) | 1 (0.3) | 1 (0.7) | |||
| Mitotic rate (%) | |||||||
| <1 | 253 (4.7) | 160 (4.8) | 0.021 | 8 (2.2) | 1 (0.7) | 0.066 | |
| 1 | 427 (8.0) | 323 (9.6) | 10 (2.7) | 2 (1.5) | |||
| ≥2 | 2,322 (43.2) | 1,462 (43.6) | 183 (49.5) | 59 (43.7) | |||
| Unknown | 2,368 (44.1) | 1,411 (42.0) | 169 (45.7) | 73 (54.1) | |||
| Ulceration (%) | |||||||
| Yes | 2,434 (45.3) | 1,321 (39.4) | <0.001 | 369 (99.7) | 135 (100.0) | 0.546 | |
| No | 2,921 (54.4) | 2,026 (60.4) | 0 (0) | 0 (0) | |||
| Unknown | 15 (0.3) | 9 (0.3) | 1 (0.3) | 0 (0) | |||