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. 2020 Nov;8(21):1373. doi: 10.21037/atm-20-2002

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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A regulatory network of circRNA-miRNA-mRNA associated with prognosis. (A) A volcano plot exhibits significantly dysregulated mRNAs between A549-R11 and A549 groups. The red points show that the miRNAs were up-regulated more than two-fold. The green points show that the miRNAs were down-regulated more than two-fold. (B) Enrichment of the top 10 GO terms (left) and KEGG pathways (right) of differentially expressed mRNAs in A549-R11 and A549 groups. (C) The Kaplan-Meier analysis of NSCLC-specific overall survival of patients with tumors expressing different levels of mRNAs. (D) A circRNA-miRNA-mRNA network correlated with the prognosis of NSCLC. Quadrilateral, triangular and rectangle nodes represent circRNAs, miRNAs and mRNAs, respectively.