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. 2020 Nov;8(21):1383. doi: 10.21037/atm-20-3295

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Diversity of bile microbiota in patients with or without sphincter of Oddi laxity (SOL). (A) α-diversity was evaluated using evenness, Shannon index, observed operational taxonomic units (OTUs), and Faith’s phylogenetic diversity (PD) index; (B) β-diversity was assessed using unweighted unifracs, weighted unifracs, and the Bray-Curtis index. P values for differences between SOL and non-SOL groups are shown; (C) linear discriminant analysis effect size (LEfSe) analysis showed that Rhizobiaceae levels were significantly different in patients with and without SOL.