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. 2020 Dec 7;26(45):7242–7257. doi: 10.3748/wjg.v26.i45.7242

Table 1.

Characteristics of included original articles and meta-analyses

Ref.
Year
Study type
No of patients
GI etiology
No of males/females
Age
Study period
Bager et al[5] 2013 Retrospective 169 Nonvariceal AUGIB 86/83 70 (22-95)1 2009
Bager et al[44] 2014 Double-blind, randomized, placebo-control 97 Nonvariceal AUGIB 51/46 70 (23-95)2 2010-2013
Bager et al[50] 2014 Double-blind, randomized, placebo-control 97 Nonvariceal AUGIB 51/46 70 (67.4-73.1)3 -
Ballester et al[45] 2019 Retrospective, single-center 84 Acute GIB 58/26 68.0 (16.9)2 2012-2015
Bosch et al[51] 2017 Prospective cohort 2818 GI diseases known to cause GIB 1398/1420 63.4 (15.7)2 2015-2016
Bosch et al[29] 2017 Prospective cohort 4552 Occult bleeding 2266/2286 63.7 (17.6)2 2005-2015
Brooklyn et al[6] 2003 N/A 153 Occult bleeding 51/102 66 (45-96)2 2000
Cheng et al[52] 2010 Prospective 390 Ulcers 263/127 63 (16)2 -
El-Halabi et al[7] 2016 Retrospective, chart review, single-center 307 Any GIB 130/177 66.2 (18.6)2 2011-2012
Geisser et al[46] 2010 Phase I/II, multicenter, open-label, multiple-dose 46 Bleeding due to GI disorder 10/36 42.9 (11.0)2 2003-2004
Jairath et al[35] 2010 Meta-analysis - AUGIB 2731/1710 Early RBC 67.9 (16.51)2; no early RBC 63.4 (19.19)2 2007
Jairath et al[36] 2015 Pragmatic, multicentric, open-label, randomized feasibility trial 936 AUGIB 566/370 Liberal 60.4 (20.0)2; restrictive 58.0 (20.3)2 2012-2013
Restellini et al[31] 2013 Observational, registry-based 1677 Nonvariceal AUGIB 1035/642 66.2 (16.8)2 1999-2002
Rockey et al[32] 2017 Prospective cohort 1460 Acute or chronic GIB 899/561 53 (14)2 2006-2011
Salvadori et al[47] 2016 Retrospective 38 GI chronic blood loss 22/16 78 (54-94)4 2014-2015
Schröder et al[48] 2004 N/A 31 GI blood loss 12/19 43.8 (18.0)2 -
Subramaniam et al[30] 2016 Retrospective cohort 2360 Nonvariceal AUGIB 1505/852 70 (56-81)4 2008-2010
Villanueva et al[37] 2013 RCT 889 Severe AUGIB - - 2003-2009
1

The median (range).

2

The mean (range) or mean (standard deviation).

3

Mean (95% confidence interval).

4

The median (Interquartile range). AUGIB: Acute upper gastrointestinal bleeding; GI: Gastrointestinal; GIB: Gastrointestinal bleeding; RBC: Red blood cell; RCT: Randomized controlled trial.