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. 2020 Dec 7;26(45):7173–7190. doi: 10.3748/wjg.v26.i45.7173

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Correlations between differential bacteria at the genus level using linear discriminant analysis effect size analysis and fecal metabolites. The heatmap presents the Spearman correlation coefficients between fecal metabolites and genera with significantly different relative abundance in the colorectal cancer (CRC) patients and healthy controls (HCs). Indoles were positively related to the genera Asaccharobacter (Actinobacteria) and Parabacteroides (Bacteroidetes), and members of the phylum Firmicutes (such as Clostridium XlVb, Fusicatenibacter, Anaerofilum, and Anaerostipes), whose relative abundances were lower in CRC patients than in HCs in the linear discriminant analysis effect size analysis. ^aP < 0.05, ^bP < 0.01. HC: Healthy control; CRC: Colorectal cancer. IPA: Indole-3-propionic acid; IAA: Indole-3-acid-acetic; KYN: Kynurenine; Trp: Tryptophan.