TABLE 1.

Fatty acid amide hydrolase (FAAH) and soluble epoxide hydrolase (sEH) inhibitory activities and docking scores of analogs

Compound	R	FAAH IC50 (nM)	sEH IC50 (nM)	Docking Score FAAH	Docking Score sEH
URB 597	-	38	-	−31.45	−22.16
AUDA	-	-	2.6	−22.18	−25.83
4-1		16	420	−21.04	−22.35
4-2		2700	5900	−12.3	−21.02
4-3		8.6	1100	−23.77	−30.32
4-4		1.3	150	−28.05	−32.42
4-5		7	9.6	−28.93	−33.03
4-6		6.1	24	−26.88	−30.93
4-7		9.6	35	−34.41	−32.44
4-8		80	26	−29.93	−32.98
4-9		13.4	1700	−35.20	−34.19
4-10		7.2	2400	−32.98	−29.41
4-11		51.6	1100	−32.17	−29.25
4-12		7	940	−36.5	−30.08
4-13		14.6	620	−26.88	−32.16
4-14		77	1300	−19.99	−28.91
4-15		260	710	−22.49	−27.61
4-16		185	580	−23.64	−31.23
4-17		>10000	370	−29.02	−32.60
4-x18		>10000	84	−18.66	−31.59
4-19		11.4	195	−27.22	−33.84
4-20		31.3	13.1	−23.64	−34.11
4-21		10	36	−37.38	−34.20
4-22		5.5	29.2	−33.14	−32.08
4-23		36.2	180	−33.22	−34.47
4-24		>10000	1100	−36.69	−32.39
4-25		>10000	3600	−41.62	−33.18
4-26		250	6600	−26.88	−30.58
4-27		270	1300	−33.37	−29.05
4-28		84	790	−28.97	−31.33
4-29		2233	840	−18.61	−24.48
4-30		>10000	2670	−37.58	−27.90