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. 2020 Dec 9;184(1):106–119.e14. doi: 10.1016/j.cell.2020.12.004

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Figure S2 — Comparison of CRISPR Screens Reveals Common and Distinct Host Factors across SARS-CoV-2, 229E, and OC43, Related to Figure 1

(A) CRISPR screen ranking of genes (according to MaGECK enrichment scores in Table S1) clustered in specific cellular pathway or complexes across the three CRISPR screens.

(B) Pairwise comparisons of gene enrichments between CRISPR screens. Dotted lines indicate -log₁₀(Enrichment score) = 3. Genes that scored above the threshold in both screens are highlighted in red.

(C) Representation of the 332 high-confidence SARS-CoV-2 protein-protein interactome hits from (Gordon et al., 2020a) (highlighted in red) within the ranked CRISPR screen data for SARS-CoV-2, OC43 and 229E infection. Gene labels are added for interactome hits that scored in the top 500 of the CRISPR screens.