Figure S3.

Network Propagation of CRISPR Screen Hits Reveals Functional Clusters with Distinct Biological Functions, Related to Figure 2

(A) Biological subclusters from network propagation. Cluster number refers to the enrichment analysis of biological processes for each cluster, displayed in Figure S3B. Circle size represents p value from integrative network propagation permutation test (see Methods and Table S3). The CRISPR screen enrichment score of a gene from each screen is indicated by color scale within the circle.

(B) Gene ontology (GO) enrichment analysis was performed on each subcluster from the network propagation. P values were calculated by hypergeometric test and a false-discovery rate was used to account for multiple hypothesis testing. The entire set of enriched biological processes for each subcluster is listed in Table S2.