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. 2020 Oct 27;23:89–100. doi: 10.1016/j.omtn.2020.10.033

Figure 1.

Figure 1

The workflow of this study

The clock-like mutational signature attenuates tumor response to immune checkpoint inhibitors by contributing to exclusion of immune activation and immune infiltration in melanoma and NSCLC immunotherapy cohorts (both in WES-Seq and Target-Seq tumors).