Figure 3.

Melanoma driver gene mutation associated with clock-like signature status

(A) Driver genes with mutation clustering detected by OncodriveCLUST. (B) Mutational landscape of the five driver genes in the melanoma cohort with different colors indicating different variant classifications. (C) Forest plot of the gene mutation frequency associated with clock-like signature status. p value was calculated by Fisher’s exact test. Driver genes also identified by the MutsigCV algorithm are highlighted with the upper right asterisk.