Figure 6.

Significantly enriched pathways and immune infiltration alteration with clock-like signature

(A) Top enriched pathways in distinct clock-like signature activity groups (0 versus 1) from the melanoma cohort were assessed by using the GSEA algorithm. (B) Single-sample gene set enrichment analysis identifying the relative infiltration of immune cell subpopulations for melanoma samples with available RNA-sequencing data. (C) The relative abundance of tumor-infiltrating leukocytes (TILs) with clock-like signature grouping in lung adenocarcinoma from TCGA datasets was estimated by the CIBERSORT algorithm. Leucocyte subsets with statistically significant differences are highlighted in red. (D) Distribution of TIDE immune response prediction scores in lung adenocarcinoma (TCGA cohort) stratified by clock-like signature grouping. (E) Distribution and association of T cell-inflamed GEP in clock-like versus non-clock-like signature subgroups. p value was calculated by Wilcoxon rank-sum test. Error bars represented the 95% confidence interval.