Table 1.

miRNA-Related Cellular Processes in CRC Metastasis

Cellular Processes	miRNAs	Alteration	Downstream Targets	References
EMT	miR-205	↑	Snail, SNORD	7,25
	let-7i	↑
	miR-200b	↑	ZEB1, ZEB2	26
	miR-200c	↑
	miR-141	↑
	miR-4775	↑	Smad7	27
	miR-496	↑	RASSF6	28
	miR-192	↓	Snail	7,25
	miR-194	↓
	miR-150	↓
	miR-490-3p	↓	FRAT	29
	miR-612	↓	AKT2	30
	miR-219-5p	↓	LEF1	31
	miR-185	↓	STIM1	32
	miR-296	↓	S100A4	33
	miR-421	↓	MTA1	34
Angiogenesis	miR-1249	↓	VEGFA, HMGA	35
	miR-590-5p	↓	NF90, VEGFA	36
	miR-25-3p	↑	KLF2, KLF4, VEGFR2, ZO-1	37
Hypoxia	miR-17~92	↓	HIF-1α, TGFBR2, VEGFA	8
	miR-145	↓	IRS1, HIF-1α	38
	miR-143	↓	IGF-1R	39
ECM remodeling	let-7c-5p	↓	COL1A2	40
	miR-20a	↓	MMP2	41
	miR-495	↓
	miR-155-5p	↓	MDEBRG1	42
	miR-21-5p	↓
TAM polarization	miR-195-5p	↑	NOTCH2, GATA3, IL-4	43
	miR-506-3p	↓	IL-6, CCL2	44
Interaction with TME via TNF-α	miR-19a	↓	TNF-α	45
	miR-105	↑	NF-κB, TNF-α, RAP2C	46

SNORD, small nucleolar RNAs with C/D motifs; ZEB1, zinc finger E-box binding homeobox 1; RASSF6, Ras association domain family member 6; STIM1, stromal interaction molecule 1; FRAT, frequently rearranged in advanced T cell lymphoma; S100A4, S100 calcium-binding protein A4; AKT2, AKT serine/threonine kinase 2; LEF1, lymphoid enhancer-binding factor 1; Gli1, GLI family zinc finger 1; MTA1, metastasis-associated protein 1; FoxQ1, forkhead box Q1; CCL2, C-C motif chemokine ligand 2; IL-6, interleukin 6; JAK2, Janus kinase 2; VEGFA, vascular endothelial growth factor A; HMGA, high mobility group A; NF90, IL enhancer binding factor 3; ZO-1, tight junction protein 1; KLF2, Krüpple-like factor 2; HIF-1α, hypoxia inducible factor-1α; IGF-1R, insulin-like growth factor 1 receptor; TGFBR2, transforming growth factor-β receptor type-2; IRS1, insulin receptor substrate 1; TNF-α, tumor necrosis factor alpha; NAT10, N-acetyltransferase 10; NF-κB, nuclear factor κB subunit 1; TAM, tumor-associated macrophage; Notch2, notch receptor 2; GATA3, GATA binding protein 3; IL-4, interleukin 4.