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. 2020 Oct 27;19:332–343. doi: 10.1016/j.omto.2020.10.012

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Replication of Oncolytic Adenoviruses Expressing miR-1 or miR-26b in Cancer Cells

(A) Analysis of adenovirus DNA copy numbers in A549 cells infected with AdΔ24E3-U6, AdΔ24E3-U6.pri-miR-1, or AdΔ24E3-U6.pri-miR-26b by qPCR for adenovirus packaging signal sequences. Data shown are the means of two independent experiments in duplicate. (B) Dose-response cytotoxicity analysis of AdΔ24E3-U6, AdΔ24E3-U6.pri-miR-1, and AdΔ24E3-U6.pri-miR-26b on A549 cells. Data shown are means of two independent experiments in triplicate. (C) Analysis of mature miR-26b-5p levels in A549 cells 32 h after infection with AdΔ24E3-U6, AdΔ24E3-U6.pri-miR-1, or AdΔ24E3-U6.pri-miR-26b. Data shown are means of three independent experiments in duplicate and are given relative to uninfected cells.